Hasan B Alam Selected Research

Valproic Acid (Depakote)

11/2021	A single dose of valproic acid improves neurologic recovery and decreases brain lesion size in swine subjected to an isolated traumatic brain injury.
10/2021	Valproic Acid Protects Against Acute Kidney Injury in Hemorrhage and Trauma.
10/2021	Assessment of the Cytoprotective Effects of High-Dose Valproic Acid Compared to a Clinically Used Lower Dose.
1/2021	Administration of valproic acid in clinically approved dose improves neurologic recovery and decreases brain lesion size in swine subjected to hemorrhagic shock and traumatic brain injury.
1/2021	Brain proteomic changes by histone deacetylase inhibition after traumatic brain injury.
1/2021	Validation of intraosseous delivery of valproic acid in a swine model of polytrauma.
1/2021	Modulation of Brain Transcriptome by Combined Histone Deacetylase Inhibition and Plasma Treatment Following Traumatic Brain Injury and Hemorrhagic Shock.
12/2020	Valproic acid treatment rescues injured tissues after traumatic brain injury.
11/2020	Histone deacetylase 6 inhibition improves survival in a swine model of lethal hemorrhage, polytrauma, and bacteremia.
10/2020	Valproic acid decreases resuscitation requirements after hemorrhage in a prolonged damage-control resuscitation model.

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Hasan B Alam Research Topics

Disease

80	Hemorrhagic Shock 01/2021 - 01/2002
79	Hemorrhage 01/2022 - 01/2002
63	Shock 01/2022 - 08/2002
49	Wounds and Injuries (Trauma) 01/2022 - 08/2002
37	Traumatic Brain Injuries (Traumatic Brain Injury) 11/2022 - 07/2012
19	Multiple Trauma (Multiple Injuries) 10/2021 - 11/2008
18	Inflammation (Inflammations) 11/2022 - 05/2002
18	Hypothermia 11/2017 - 01/2005
17	Sepsis (Septicemia) 05/2021 - 06/2014
14	Hypoxia (Hypoxemia) 10/2021 - 03/2003
12	Septic Shock (Toxic Shock Syndrome) 02/2021 - 11/2009
8	Brain Edema (Cerebral Edema) 02/2020 - 12/2012
7	Infections 02/2021 - 01/2012
7	Brain Injuries (Brain Injury) 02/2020 - 12/2012
7	Acute Lung Injury 08/2018 - 04/2011
6	Ischemia 10/2020 - 03/2003
5	Acidosis 03/2011 - 06/2003
4	Stroke (Strokes) 01/2022 - 09/2008
4	Neoplasms (Cancer) 10/2020 - 11/2010
4	Heart Arrest (Cardiac Arrest) 03/2020 - 07/2010
4	Rib Fractures (Rib Fracture) 01/2014 - 03/2011
3	Appendicitis 03/2022 - 11/2020
3	Lacerations 10/2021 - 11/2003
3	Pneumonia (Pneumonitis) 01/2021 - 12/2011
3	Hypotension (Low Blood Pressure) 01/2021 - 05/2013
3	Myocardial Infarction 10/2020 - 01/2019
3	Endotoxemia 08/2020 - 08/2013
3	Lactic Acidosis 03/2020 - 01/2006
3	Atrophy 11/2016 - 08/2014
3	Vascular System Injuries 04/2008 - 01/2002
3	Hyperkalemia 01/2006 - 11/2004
2	Cholecystitis 03/2021 - 01/2016
2	Hematoma 11/2017 - 03/2011

Drug/Important Bio-Agent (IBA)

51	Valproic Acid (Depakote)FDA LinkGeneric 11/2021 - 04/2006
45	Histone Deacetylase InhibitorsIBA 01/2021 - 03/2006
31	Saline SolutionIBA 10/2021 - 01/2006
23	salicylhydroxamic acid (SHAM)IBA 02/2016 - 08/2002
21	Histones (Histone)IBA 05/2021 - 03/2006
17	Histone Deacetylases (Histone Deacetylase)IBA 01/2021 - 03/2006
16	Proteins (Proteins, Gene)FDA Link 11/2022 - 03/2003
14	LipopolysaccharidesIBA 05/2021 - 08/2008
13	Ringer's LactateIBA 01/2022 - 08/2002
12	Biomarkers (Surrogate Marker)IBA 01/2021 - 08/2005
12	SolutionsIBA 12/2017 - 01/2006
12	Vorinostat FDA Link 04/2015 - 11/2009
11	Hydroxyethyl Starch Derivatives (Pentastarch)FDA Link 01/2018 - 01/2006
11	KetonesIBA 02/2008 - 05/2002
10	Lactic Acid (Lactate)FDA LinkGeneric 01/2019 - 08/2004
10	Pyruvic Acid (Pyruvate)IBA 12/2013 - 08/2003
9	Protein-Arginine DeiminasesIBA 05/2021 - 08/2014
9	Hemostatics (Antihemorrhagics)IBA 08/2014 - 06/2003
8	CytokinesIBA 11/2016 - 03/2003
7	Histone Deacetylase 6IBA 11/2020 - 07/2015
6	Anti-Bacterial Agents (Antibiotics)IBA 03/2022 - 09/2010
5	EnzymesIBA 05/2021 - 08/2010
5	Protein Isoforms (Isoforms)IBA 11/2020 - 01/2016
5	Caspase 3 (Caspase-3)IBA 01/2019 - 07/2009
5	tubastatin AIBA 12/2018 - 07/2015
5	Sodium Chloride FDA LinkGeneric 12/2017 - 06/2005
4	Ringer's SolutionIBA 03/2006 - 11/2005
4	N 30IBA 01/2006 - 08/2003
3	Carbon DioxideIBA 01/2022 - 08/2007
3	CalciumIBA 10/2021 - 01/2019
3	N- alpha- benzoyl- N5- (2- chloro- 1- iminoethyl)- L- ornithine amideIBA 05/2021 - 08/2014
3	Pharmaceutical PreparationsIBA 01/2021 - 06/2005
3	TubulinIBA 01/2019 - 01/2016
3	Phosphotransferases (Kinase)IBA 01/2019 - 09/2010
3	ACY1083IBA 01/2019 - 01/2018
3	Adenosine Diphosphate (ADP)IBA 09/2017 - 05/2013
3	Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA 02/2016 - 09/2007
3	Interleukin-6 (Interleukin 6)IBA 02/2016 - 08/2005
3	Messenger RNA (mRNA)IBA 08/2012 - 03/2003
3	ZeolitesIBA 12/2006 - 05/2004
2	Fatty Acids (Saturated Fatty Acids)IBA 10/2021 - 12/2016
2	Adenosine Triphosphate (ATP)IBA 10/2021 - 01/2006
2	Biological ProductsIBA 01/2021 - 12/2014
2	Monoclonal AntibodiesIBA 01/2021 - 01/2019
2	InflammasomesIBA 01/2021 - 01/2018
2	Neuroprotective AgentsIBA 01/2021 - 08/2014
2	Glial Fibrillary Acidic ProteinIBA 01/2019 - 01/2018
2	CyclodextrinsIBA 01/2019 - 01/2018
2	MC1568IBA 01/2019 - 01/2018
2	YW3-56IBA 08/2018 - 02/2016
2	Toll-Like Receptors (Toll-Like Receptor)IBA 01/2018 - 09/2007
2	Mitogen-Activated Protein KinasesIBA 01/2018 - 07/2012
2	CollagenIBA 09/2017 - 01/2017

Therapy/Procedure

84	Resuscitation 01/2022 - 01/2002
13	Therapeutics 01/2022 - 03/2010
9	Ligation 10/2020 - 09/2008
9	Cardiopulmonary Bypass (Heart-Lung Bypass) 07/2010 - 06/2005
8	Punctures 12/2018 - 08/2013
7	Thoracotomy 11/2017 - 08/2002
6	Length of Stay 10/2016 - 12/2011
6	Induced Hypothermia 06/2015 - 01/2009
5	Catheters 01/2018 - 01/2006
4	Laparotomy 01/2017 - 08/2008
4	Anesthesia 05/2013 - 11/2003
3	Appendectomy 03/2022 - 11/2020
3	Blood Transfusion (Blood Transfusions) 01/2012 - 08/2009
2	Airway Management 01/2020 - 01/2012